After disabling the ability to wake-up the system in Windows Device Manager, the Unifying mouse or keyboard still brings the system out of sleep mode.
Even if you bought a mouse-only or keyboard-only product, the Unifying receiver that came with it still enumerates for both the mouse and keyboard interfaces.
If you have two mice attached, then you would need to uncheck the "Allow this device to wake the computer" option for both mice plus a keyboard in the Windows Device Manager.
Use the process below to identify and configure the Unifying devices to not wake up the system in Windows Device Manager.
Changing wake-up settings in the Device Manager
To change the wake-up settings in Windows Device Manager, you'll need to launch it through Computer Management and then make your selections. Here's how:
Click Start, right-click Computer, and then click Manage.
Click Device Manager in the navigation pane on the left.
Select and expand either the "Keyboards" or "Mice and other pointing devices" category.
Right-click on the first entry and go to Properties > Details tab > Hardware IDs under the Property section.
Make sure the Value section contains: HID\VID_046D&PID_C52B. If it doesn't, click Cancel and open the next mouse or keyboard entry in the list.
Select the "Power Management" tab and uncheck the "Allow this device to wake the computer" check box.
Repeat the same steps for all entries in both the "Keyboards" and "Mice and other pointing devices" categories.