H650e audio will work with any application that supports the USB standard, which is pretty much any video conferencing application.  Once the device is recognized by your operating system, the application will in turn automatically recognize the microphone and speaker from the H650e.  
 
A partial list of  applications that support H650e include Skype for Business, Microsoft Teams, Zoom, Google Hangouts, BlueJeans, Cisco Jabber, and dozens of others.